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| Second Basemen Career Slugging Pct Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Slugging Pct | PA | Years | Single Season Leaderboard |
| 1. | Summer Nelson * | .4867 | 13326 | 2000-2020 | |
| 2. | Seamus O'Dule * | .4848 | 11331 | 2002-2021 | |
| 3. | Lane Commons * | .4782 | 9290 | 2003-2017 | |
| 4. | Blinky Crouch | .4657 | 6751 | 2018-2029 | |
| 5. | Adam Anderson | .4649 | 8316 | 2001-2016 | |
| 6. | Rey Moncayo * | .4645 | 7698 | 2002-2014 | |
| 7. | Gary Crawford | .4617 | 5657 | 2000-2009 | |
| 8. | Andrew Wilson | .4544 | 3737 | 2024-2029 | |
| 9. | Bob Medforth | .4536 | 6924 | 2018-2029 | |
| 10. | Brian Marshall * | .4521 | 12282 | 2000-2018 | |
| 11. | Antonio Ramos | .4441 | 4081 | 2000-2008 | |
| 12. | Ernest Meleschi | .4382 | 6493 | 2007-2019 | |
| 13. | William Maxon | .4348 | 4637 | 2000-2008 | |
| 14. | Joel Huertas | .4333 | 10198 | 2014-2029 | |
| 15. | Daniel Phillips | .4317 | 9012 | 2014-2028 | |
| 16. | John Honeycutt | .4314 | 3832 | 2003-2013 | |
| 17. | Howard Luther | .4304 | 5332 | 2003-2014 | |
| 18. | Bates Schatz | .4252 | 3542 | 2024-2029 | |
| 19. | Joseph Flores | .4249 | 5516 | 2019-2029 | |
| 20. | Cyril Foland | .4197 | 5514 | 2003-2013 | |
| 21. | Matthew Wolf | .4168 | 8475 | 2015-2029 | |
| 22. | David Melgoza | .4156 | 5545 | 2010-2023 | |
| 23. | Bobby Whittaker | .4140 | 6765 | 2010-2026 | |
| 24. | Ludwig Claus | .4133 | 7196 | 2005-2022 | |
| 25. | Todd Castiglia | .4110 | 5873 | 2000-2016 | |
| 26. | Anthony Godwin | .4100 | 8267 | 2015-2029 | |
| 27. | Randy McKen | .4083 | 3078 | 2012-2022 | |
| 28. | Humberto Dominguez | .3998 | 3531 | 2000-2011 | |
| 29. | Fernando Selso | .3992 | 3300 | 2024-2029 | |
| 30. | Mark Stone | .3989 | 5743 | 2018-2029 | |
| 31. | Rene Searles | .3988 | 7383 | 2011-2025 | |
| 32. | James Dickson | .3976 | 3717 | 2000-2009 | |
| 33. | Oscar Nolan | .3967 | 5379 | 2019-2029 | |
| 34. | Frederick Traynor | .3965 | 3482 | 2000-2006 | |
| 35. | Mason Highsmith | .3962 | 10686 | 2007-2024 | |
| 36. | Dan Erb | .3960 | 7384 | 2009-2021 | |
| 37. | Jeff Arnette | .3945 | 4967 | 2021-2029 | |
| 38. | Vin Koenig | .3932 | 9411 | 2007-2023 | |
| 39. | Todd Maher | .3906 | 4549 | 2000-2008 | |
| 40. | Red Rother | .3872 | 4625 | 2009-2018 | |
| 41. | Jake Kinchen | .3861 | 4878 | 2017-2029 | |
| 42. | Zachary Matthews * | .3850 | 7672 | 2000-2012 | |
| 43. | Henry Davis | .3833 | 6413 | 2005-2020 | |
| 44. | Garry Vandiver | .3746 | 4892 | 2020-2029 | |
| 45. | Jesus Tabares | .3736 | 3372 | 2022-2029 | |
| 46. | Jim Masson | .3729 | 4093 | 2016-2029 | |
| 47. | Joseph Sharkey | .3716 | 3257 | 2000-2005 | |
| 48. | Danny Rayborn | .3700 | 5328 | 2000-2008 | |
| 49. | Brett Eisen | .3688 | 3050 | 2000-2011 | |
| 50. | Eugene Hove | .3671 | 3776 | 2007-2017 | |
| 51. | Ed Parker | .3664 | 3232 | 2022-2029 | |
| 52. | Darius Mosqueda | .3663 | 4124 | 2000-2011 | |
| 53. | Bruce Howes | .3662 | 4009 | 2001-2014 | |
| 54. | Dave Dancey | .3651 | 4834 | 2020-2029 | |
| 55. | David Cimino | .3651 | 3000 | 2009-2020 | |
| 56. | Adrian Turgeon | .3628 | 3187 | 2017-2029 | |
| 57. | Harvey Thornton | .3572 | 5456 | 2016-2029 | |
| 58. | Arron Silvia | .3569 | 3452 | 2005-2013 | |
| 59. | Joe Hepler | .3554 | 4874 | 2006-2016 | |
| 60. | Tamajirou Kakuzo | .3541 | 7146 | 2015-2029 | |
| 61. | Joel Camacho | .3539 | 3453 | 2000-2005 | |
| 62. | Allen Lively | .3522 | 6045 | 2011-2022 | |
| 63. | Abe Seemann | .3495 | 5043 | 2005-2017 | |
| 64. | George Mingham | .3436 | 3211 | 2010-2023 | |
| 65. | James Erickson | .3405 | 4383 | 2005-2020 | |
| 66. | Manuel Rodriguez | .3392 | 6614 | 2007-2019 | |
| 67. | Henry Magnan | .3324 | 6019 | 2014-2027 | |
| 68. | David Reddaway | .3310 | 5023 | 2019-2029 | |
| 69. | Joshua Sidwell | .3298 | 5209 | 2014-2024 | |
| 70. | Bill Latham | .3282 | 4352 | 2007-2014 | |
| 71. | Dude Gallagher | .3175 | 3298 | 2019-2029 | |
| 72. | Samuel Warlick | .3101 | 4031 | 2001-2016 | |
| 73. | Josephus Thomas | .3045 | 5782 | 2004-2016 |
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