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| Second Basemen Single-Season Assists Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Assists | IP | Year | Career Leaderboard |
| 1. | Zachary Matthews * | 589 | 1303.7 | 2007 | |
| 2. | Eduardo Ulibarri | 586 | 1364.0 | 2014 | |
| 3. | Tony Luna | 579 | 1358.3 | 2017 | |
| 4. | Matt Lake | 571 | 1277.7 | 2025 | |
| Joe Berard | 571 | 1444.3 | 2013 | ||
| 6. | David Melgoza | 569 | 1318.7 | 2015 | |
| 7. | Bob Medforth | 568 | 1364.0 | 2026 | |
| 8. | Bobby Whittaker | 566 | 1344.0 | 2015 | |
| William Maxon | 566 | 1433.0 | 2001 | ||
| 10. | Joseph Flores | 561 | 1300.0 | 2028 | |
| 11. | Matthew Wolf | 560 | 1258.3 | 2028 | |
| 12. | Fernando Selso | 558 | 1283.0 | 2026 | |
| Matthew Courtney | 558 | 1303.3 | 2023 | ||
| 14. | Anthony Godwin | 557 | 1225.0 | 2028 | |
| 15. | William Maxon | 555 | 1439.3 | 2000 | |
| 16. | Matthew Courtney | 554 | 1265.3 | 2022 | |
| Ernest Meleschi | 554 | 1313.3 | 2010 | ||
| 18. | Brian Marshall * | 551 | 1359.7 | 2013 | |
| Adam Anderson | 551 | 1306.0 | 2010 | ||
| 20. | Vin Koenig | 549 | 1294.0 | 2012 | |
| 21. | Ludwig Claus | 548 | 1239.3 | 2015 | |
| Adam Anderson | 548 | 1313.3 | 2013 | ||
| Joe Berard | 548 | 1401.0 | 2012 | ||
| 24. | Adam Anderson | 547 | 1294.0 | 2012 | |
| 25. | Seamus O'Dule * | 545 | 1249.7 | 2020 | |
| Bobby Whittaker | 545 | 1225.0 | 2014 | ||
| 27. | Mark Stone | 543 | 1318.0 | 2027 | |
| 28. | Fernando Selso | 542 | 1254.7 | 2029 | |
| Joseph Flores | 542 | 1248.7 | 2029 | ||
| 30. | James Erickson | 541 | 1224.7 | 2010 | |
| Zachary Matthews * | 541 | 1260.0 | 2008 | ||
| 32. | Tony Luna | 539 | 1263.3 | 2022 | |
| 33. | Ernest Meleschi | 536 | 1310.3 | 2015 | |
| James Erickson | 536 | 1269.7 | 2011 | ||
| 35. | Fernando Selso | 535 | 1294.3 | 2027 | |
| 36. | Andrew Wilson | 534 | 1243.3 | 2024 | |
| 37. | Mark Stone | 533 | 1282.7 | 2028 | |
| Brian Marshall * | 533 | 1356.0 | 2012 | ||
| Adam Anderson | 533 | 1266.7 | 2011 | ||
| 40. | Brian Marshall * | 532 | 1276.3 | 2018 | |
| Ludwig Claus | 532 | 1300.3 | 2014 | ||
| 42. | Anthony Godwin | 531 | 1259.7 | 2027 | |
| Daniel Phillips | 531 | 1230.0 | 2025 | ||
| Fernando Selso | 531 | 1223.0 | 2025 | ||
| Zachary Matthews * | 531 | 1361.7 | 2000 | ||
| 46. | Joe Hepler | 530 | 1246.3 | 2011 | |
| Brian Marshall * | 530 | 1314.7 | 2010 | ||
| 48. | Matt Lake | 529 | 1112.0 | 2024 | |
| Lane Commons * | 529 | 1358.7 | 2014 | ||
| 50. | Matthew Wolf | 528 | 1321.0 | 2025 | |
| Rex Spikes | 528 | 1338.7 | 2012 | ||
| 52. | Ludwig Claus | 527 | 1313.0 | 2010 | |
| 53. | Tamajirou Kakuzo | 526 | 1267.7 | 2026 | |
| Brian Marshall * | 526 | 1337.7 | 2016 | ||
| William Maxon | 526 | 1259.3 | 2003 | ||
| 56. | Joe Hepler | 524 | 1221.0 | 2012 | |
| 57. | Daniel Phillips | 523 | 1294.7 | 2024 | |
| Seamus O'Dule * | 523 | 1315.3 | 2018 | ||
| Bobby Whittaker | 523 | 1297.7 | 2016 | ||
| Seamus O'Dule * | 523 | 1331.7 | 2013 | ||
| 61. | Issac Phillips | 522 | 1326.3 | 2026 | |
| 62. | Jade Sanchez | 521 | 1313.3 | 2026 | |
| John Carsswell | 521 | 1312.0 | 2017 | ||
| Ludwig Claus | 521 | 1273.0 | 2013 | ||
| Brian Marshall * | 521 | 1325.7 | 2011 | ||
| Zachary Matthews * | 521 | 1288.3 | 2002 | ||
| 67. | Fernando Selso | 520 | 1282.7 | 2028 | |
| Joel Huertas | 520 | 1353.0 | 2019 | ||
| Bill Latham | 520 | 1257.0 | 2010 | ||
| 70. | Bill Latham | 519 | 1241.3 | 2009 | |
| Zachary Matthews * | 519 | 1359.0 | 2001 | ||
| 72. | Ludwig Claus | 518 | 1253.7 | 2012 | |
| 73. | Eugene Hove | 517 | 1300.0 | 2009 | |
| Frederick Traynor | 517 | 1335.0 | 2001 | ||
| 75. | Matthew Wolf | 516 | 1269.3 | 2024 | |
| Archy Miller Jr | 516 | 1253.0 | 2013 | ||
| 77. | Lee Viga | 515 | 1266.0 | 2029 | |
| Joseph Flores | 515 | 1246.7 | 2019 | ||
| 79. | Mason Highsmith | 514 | 1338.7 | 2017 | |
| 80. | Joseph Flores | 513 | 1281.0 | 2027 | |
| Ernest Meleschi | 513 | 1319.0 | 2009 | ||
| 82. | Zachary Matthews * | 512 | 1212.3 | 2011 | |
| Zachary Matthews * | 512 | 1320.3 | 2003 | ||
| 84. | Tamajirou Kakuzo | 511 | 1205.7 | 2024 | |
| Daniel Phillips | 511 | 1333.0 | 2022 | ||
| August Osvald | 511 | 1269.7 | 2022 | ||
| 87. | Mason Highsmith | 510 | 1235.7 | 2019 | |
| Ernest Meleschi | 510 | 1230.0 | 2017 | ||
| 89. | Joel Huertas | 509 | 1272.7 | 2018 | |
| 90. | Mason Highsmith | 508 | 1330.3 | 2016 | |
| Joe Hepler | 508 | 1255.7 | 2015 | ||
| Frederick Traynor | 508 | 1292.7 | 2002 | ||
| 93. | Anthony Godwin | 507 | 1345.3 | 2024 | |
| Brian Marshall * | 507 | 1299.3 | 2015 | ||
| Daniel Phillips | 507 | 1276.3 | 2015 | ||
| Joe Hepler | 507 | 1204.0 | 2014 | ||
| Todd Maher | 507 | 1320.3 | 2001 | ||
| 98. | Brian Marshall * | 506 | 1241.0 | 2014 | |
| Zachary Matthews * | 506 | 1172.3 | 2009 | ||
| 100. | Roger Aker | 505 | 1233.3 | 2029 |
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