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| Second Basemen Single-Season Games Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Games | PA | Year | Career Leaderboard |
| 1. | Jesus Tabares | 162 | 672 | 2027 | |
| Bo Dimattia | 162 | 658 | 2017 | ||
| Josephus Thomas | 162 | 709 | 2012 | ||
| Todd Maher | 162 | 730 | 2004 | ||
| Albert Estrada | 162 | 620 | 2002 | ||
| Antonio Ramos | 162 | 710 | 2001 | ||
| William Maxon | 162 | 706 | 2001 | ||
| 8. | Brian Marshall * | 161 | 757 | 2001 | |
| Summer Nelson * | 161 | 718 | 2001 | ||
| Gary Crawford | 161 | 686 | 2001 | ||
| Frederick Traynor | 161 | 613 | 2001 | ||
| Danny Rayborn | 161 | 722 | 2000 | ||
| 13. | Eduardo Ulibarri | 160 | 684 | 2014 | |
| Summer Nelson * | 160 | 679 | 2008 | ||
| Todd Maher | 160 | 637 | 2003 | ||
| Brian Marshall * | 160 | 762 | 2000 | ||
| William Maxon | 160 | 702 | 2000 | ||
| Jose Abdullah | 160 | 575 | 2000 | ||
| 19. | Anthony Godwin | 159 | 631 | 2027 | |
| Blinky Crouch | 159 | 663 | 2025 | ||
| Jeff Arnette | 159 | 682 | 2024 | ||
| Matthew Wolf | 159 | 617 | 2024 | ||
| Mason Highsmith | 159 | 669 | 2020 | ||
| Bob Medforth | 159 | 686 | 2019 | ||
| Summer Nelson * | 159 | 615 | 2017 | ||
| Seamus O'Dule * | 159 | 651 | 2006 | ||
| Joel Camacho | 159 | 698 | 2001 | ||
| Joseph Sharkey | 159 | 672 | 2000 | ||
| David Strothers | 159 | 663 | 2000 | ||
| 30. | Tamajirou Kakuzo | 158 | 639 | 2029 | |
| Fernando Selso | 158 | 644 | 2028 | ||
| Anthony Godwin | 158 | 648 | 2025 | ||
| Joel Huertas | 158 | 698 | 2024 | ||
| Anthony Godwin | 158 | 660 | 2024 | ||
| Blinky Crouch | 158 | 653 | 2023 | ||
| Jake Kinchen | 158 | 638 | 2022 | ||
| Anthony Godwin | 158 | 661 | 2021 | ||
| Bob Medforth | 158 | 656 | 2021 | ||
| Bob Medforth | 158 | 654 | 2020 | ||
| Mason Highsmith | 158 | 654 | 2018 | ||
| Bob Medforth | 158 | 632 | 2018 | ||
| Joel Huertas | 158 | 686 | 2017 | ||
| Daniel Phillips | 158 | 630 | 2017 | ||
| Lane Commons * | 158 | 680 | 2016 | ||
| Bobby Whittaker | 158 | 593 | 2016 | ||
| Seamus O'Dule * | 158 | 662 | 2015 | ||
| Henry Davis | 158 | 618 | 2015 | ||
| Dan Erb | 158 | 632 | 2014 | ||
| Red Rother | 158 | 624 | 2012 | ||
| James Erickson | 158 | 628 | 2011 | ||
| Ernest Meleschi | 158 | 619 | 2010 | ||
| Ludwig Claus | 158 | 607 | 2009 | ||
| Rey Moncayo * | 158 | 678 | 2007 | ||
| Summer Nelson * | 158 | 651 | 2006 | ||
| Joel Camacho | 158 | 659 | 2002 | ||
| James Dickson | 158 | 620 | 2000 | ||
| 57. | Looney Garmendia | 157 | 680 | 2029 | |
| Matthew Wolf | 157 | 617 | 2028 | ||
| Andrew Wilson | 157 | 699 | 2027 | ||
| Andrew Wilson | 157 | 661 | 2025 | ||
| Jade Sanchez | 157 | 640 | 2025 | ||
| Adrian Turgeon | 157 | 606 | 2025 | ||
| Blinky Crouch | 157 | 648 | 2024 | ||
| Jeff Arnette | 157 | 680 | 2023 | ||
| Anthony Godwin | 157 | 693 | 2022 | ||
| Vin Koenig | 157 | 592 | 2021 | ||
| Seamus O'Dule * | 157 | 609 | 2020 | ||
| Daniel Phillips | 157 | 648 | 2019 | ||
| Joel Huertas | 157 | 703 | 2018 | ||
| Dan Erb | 157 | 641 | 2018 | ||
| Bobby Whittaker | 157 | 627 | 2018 | ||
| Lane Commons * | 157 | 633 | 2017 | ||
| Mason Highsmith | 157 | 649 | 2016 | ||
| Joshua Sidwell | 157 | 463 | 2016 | ||
| Daniel Phillips | 157 | 647 | 2015 | ||
| Vin Koenig | 157 | 627 | 2015 | ||
| Lane Commons * | 157 | 697 | 2014 | ||
| Lane Commons * | 157 | 671 | 2013 | ||
| Allen Lively | 157 | 649 | 2012 | ||
| Ludwig Claus | 157 | 627 | 2012 | ||
| Manuel Rodriguez | 157 | 556 | 2012 | ||
| Seamus O'Dule * | 157 | 646 | 2011 | ||
| Seamus O'Dule * | 157 | 660 | 2010 | ||
| Ernest Meleschi | 157 | 627 | 2009 | ||
| Howard Luther | 157 | 596 | 2009 | ||
| Lane Commons * | 157 | 659 | 2008 | ||
| Seamus O'Dule * | 157 | 652 | 2008 | ||
| Danny Rayborn | 157 | 602 | 2006 | ||
| Howard Luther | 157 | 600 | 2006 | ||
| Gary Crawford | 157 | 613 | 2005 | ||
| Danny Rayborn | 157 | 573 | 2005 | ||
| Danny Rayborn | 157 | 610 | 2004 | ||
| Danny Rayborn | 157 | 621 | 2003 | ||
| Joseph Sharkey | 157 | 697 | 2001 | ||
| 95. | Jack Hesse | 156 | 704 | 2029 | |
| Matthew Wolf | 156 | 622 | 2029 | ||
| Looney Garmendia | 156 | 624 | 2028 | ||
| Jack Hesse | 156 | 673 | 2027 | ||
| Fernando Selso | 156 | 651 | 2027 | ||
| Bob Medforth | 156 | 635 | 2027 |
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