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| Second Basemen Career Total Bases Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Total Bases | PA | Years | Single Season Leaderboard |
| 1. | Summer Nelson * | 5907 | 13326 | 2000-2020 | |
| 2. | Brian Marshall * | 4910 | 12282 | 2000-2018 | |
| 3. | Seamus O'Dule * | 4708 | 11331 | 2002-2021 | |
| 4. | Joel Huertas | 3966 | 10198 | 2014-2029 | |
| 5. | Mason Highsmith | 3912 | 10686 | 2007-2024 | |
| 6. | Lane Commons * | 3898 | 9290 | 2003-2017 | |
| 7. | Daniel Phillips | 3498 | 9012 | 2014-2028 | |
| 8. | Adam Anderson | 3485 | 8316 | 2001-2016 | |
| 9. | Vin Koenig | 3417 | 9411 | 2007-2023 | |
| 10. | Matthew Wolf | 3161 | 8475 | 2015-2029 | |
| 11. | Rey Moncayo * | 3005 | 7698 | 2002-2014 | |
| 12. | Anthony Godwin | 2963 | 8267 | 2015-2029 | |
| 13. | Bob Medforth | 2892 | 6924 | 2018-2029 | |
| 14. | Rene Searles | 2727 | 7383 | 2011-2025 | |
| 15. | Zachary Matthews * | 2713 | 7672 | 2000-2012 | |
| 16. | Dan Erb | 2655 | 7384 | 2009-2021 | |
| 17. | Blinky Crouch | 2596 | 6751 | 2018-2029 | |
| 18. | Bobby Whittaker | 2565 | 6765 | 2010-2026 | |
| 19. | Ernest Meleschi | 2560 | 6493 | 2007-2019 | |
| 20. | Ludwig Claus | 2542 | 7196 | 2005-2022 | |
| 21. | Gary Crawford | 2422 | 5657 | 2000-2009 | |
| 22. | Tamajirou Kakuzo | 2333 | 7146 | 2015-2029 | |
| 23. | Todd Castiglia | 2292 | 5873 | 2000-2016 | |
| 24. | Henry Davis | 2233 | 6413 | 2005-2020 | |
| 25. | Cyril Foland | 2153 | 5514 | 2003-2013 | |
| 26. | Howard Luther | 2121 | 5332 | 2003-2014 | |
| 27. | David Melgoza | 2086 | 5545 | 2010-2023 | |
| 28. | Joseph Flores | 2054 | 5516 | 2019-2029 | |
| 29. | Manuel Rodriguez | 2039 | 6614 | 2007-2019 | |
| 30. | Mark Stone | 1970 | 5743 | 2018-2029 | |
| 31. | Allen Lively | 1964 | 6045 | 2011-2022 | |
| 32. | Oscar Nolan | 1942 | 5379 | 2019-2029 | |
| 33. | William Maxon | 1854 | 4637 | 2000-2008 | |
| 34. | Henry Magnan | 1849 | 6019 | 2014-2027 | |
| 35. | Harvey Thornton | 1815 | 5456 | 2016-2029 | |
| 36. | Jeff Arnette | 1814 | 4967 | 2021-2029 | |
| 37. | Danny Rayborn | 1751 | 5328 | 2000-2008 | |
| 38. | Jake Kinchen | 1739 | 4878 | 2017-2029 | |
| 39. | Red Rother | 1652 | 4625 | 2009-2018 | |
| 40. | Josephus Thomas | 1639 | 5782 | 2004-2016 | |
| 41. | Todd Maher | 1621 | 4549 | 2000-2008 | |
| 42. | Antonio Ramos | 1620 | 4081 | 2000-2008 | |
| 43. | Abe Seemann | 1607 | 5043 | 2005-2017 | |
| 44. | Joshua Sidwell | 1599 | 5209 | 2014-2024 | |
| 45. | Joe Hepler | 1586 | 4874 | 2006-2016 | |
| 46. | Dave Dancey | 1577 | 4834 | 2020-2029 | |
| 47. | Garry Vandiver | 1560 | 4892 | 2020-2029 | |
| 48. | David Reddaway | 1534 | 5023 | 2019-2029 | |
| 49. | Andrew Wilson | 1519 | 3737 | 2024-2029 | |
| 50. | John Honeycutt | 1510 | 3832 | 2003-2013 | |
| 51. | Darius Mosqueda | 1397 | 4124 | 2000-2011 | |
| 52. | James Erickson | 1393 | 4383 | 2005-2020 | |
| 53. | Bates Schatz | 1375 | 3542 | 2024-2029 | |
| 54. | James Dickson | 1374 | 3717 | 2000-2009 | |
| 55. | Jim Masson | 1373 | 4093 | 2016-2029 | |
| 56. | Bruce Howes | 1366 | 4009 | 2001-2014 | |
| 57. | Bill Latham | 1332 | 4352 | 2007-2014 | |
| 58. | Humberto Dominguez | 1281 | 3531 | 2000-2011 | |
| 59. | Eugene Hove | 1269 | 3776 | 2007-2017 | |
| 60. | Frederick Traynor | 1266 | 3482 | 2000-2006 | |
| 61. | Fernando Selso | 1212 | 3300 | 2024-2029 | |
| 62. | Randy McKen | 1156 | 3078 | 2012-2022 | |
| 63. | Samuel Warlick | 1141 | 4031 | 2001-2016 | |
| 64. | Jesus Tabares | 1129 | 3372 | 2022-2029 | |
| 65. | Joel Camacho | 1118 | 3453 | 2000-2005 | |
| 66. | Joseph Sharkey | 1098 | 3257 | 2000-2005 | |
| 67. | Arron Silvia | 1085 | 3452 | 2005-2013 | |
| 68. | Adrian Turgeon | 1083 | 3187 | 2017-2029 | |
| 69. | Ed Parker | 1067 | 3232 | 2022-2029 | |
| 70. | Keith Johnson | 1060 | 2991 | 2000-2010 | |
| 71. | Jack Hesse | 1055 | 2654 | 2026-2029 | |
| 72. | George Mingham | 1044 | 3211 | 2010-2023 | |
| 73. | Brett Eisen | 1040 | 3050 | 2000-2011 | |
| 74. | David Cimino | 1008 | 3000 | 2009-2020 | |
| 75. | Jose Abdullah | 949 | 2622 | 2000-2005 | |
| 76. | Bob Pyne | 942 | 2749 | 2021-2029 | |
| 77. | Matt Lake | 941 | 2952 | 2023-2029 | |
| 78. | Snap Collins | 925 | 2571 | 2022-2029 | |
| 79. | Howard Pierre | 913 | 2924 | 2016-2027 | |
| 80. | Jade Sanchez | 890 | 2704 | 2025-2029 | |
| 81. | Dude Gallagher | 874 | 3298 | 2019-2029 | |
| 82. | Larry Place | 864 | 2523 | 2000-2006 | |
| 83. | Looney Garmendia | 844 | 1902 | 2027-2029 | |
| 84. | Leon Nickles | 814 | 2183 | 2025-2029 | |
| 85. | Luis Osalde | 813 | 2476 | 2021-2029 | |
| 86. | Bob Hamada | 789 | 2474 | 2017-2028 | |
| 87. | Robert Souders | 774 | 2154 | 2003-2013 | |
| 88. | Vernon Rainwater | 748 | 2617 | 2003-2013 | |
| 89. | David Strothers | 702 | 1954 | 2000-2006 | |
| 90. | Hector Rodriguez | 660 | 1831 | 2000-2002 | |
| 91. | Alexander Bologna | 648 | 1770 | 2000-2003 | |
| 92. | Roger Aker | 637 | 1694 | 2025-2029 | |
| 93. | Antonio Defazio | 634 | 2273 | 2002-2013 | |
| 94. | Alan Gast | 633 | 1678 | 2024-2028 | |
| 95. | Eduardo Ulibarri | 627 | 2373 | 2005-2015 | |
| 96. | Matthew Dismukes | 624 | 1941 | 2000-2005 | |
| 97. | William Kulas | 600 | 1838 | 2000-2009 | |
| 98. | Alberto Aceves | 533 | 1893 | 2012-2021 | |
| 99. | Lynn Labrecque | 523 | 1701 | 2007-2016 | |
| 100. | Don Tye | 491 | 1669 | 2011-2022 |
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