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| Second Basemen Career Homeruns Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Homeruns | PA | Years | Single Season Leaderboard |
| 1. | Summer Nelson * | 497 | 13326 | 2000-2020 | |
| 2. | Seamus O'Dule * | 376 | 11331 | 2002-2021 | |
| 3. | Brian Marshall * | 351 | 12282 | 2000-2018 | |
| 4. | Daniel Phillips | 279 | 9012 | 2014-2028 | |
| 5. | Ludwig Claus | 272 | 7196 | 2005-2022 | |
| 6. | Blinky Crouch | 269 | 6751 | 2018-2029 | |
| 7. | Lane Commons * | 264 | 9290 | 2003-2017 | |
| 8. | Ernest Meleschi | 263 | 6493 | 2007-2019 | |
| 9. | Gary Crawford | 262 | 5657 | 2000-2009 | |
| 10. | Joel Huertas | 259 | 10198 | 2014-2029 | |
| 11. | Bob Medforth | 252 | 6924 | 2018-2029 | |
| 12. | Rey Moncayo * | 235 | 7698 | 2002-2014 | |
| 13. | Anthony Godwin | 226 | 8267 | 2015-2029 | |
| Adam Anderson | 226 | 8316 | 2001-2016 | ||
| 15. | Bobby Whittaker | 215 | 6765 | 2010-2026 | |
| 16. | Matthew Wolf | 208 | 8475 | 2015-2029 | |
| 17. | William Maxon | 198 | 4637 | 2000-2008 | |
| 18. | Henry Davis | 195 | 6413 | 2005-2020 | |
| 19. | Cyril Foland | 193 | 5514 | 2003-2013 | |
| 20. | Vin Koenig | 170 | 9411 | 2007-2023 | |
| 21. | Zachary Matthews * | 165 | 7672 | 2000-2012 | |
| 22. | David Melgoza | 164 | 5545 | 2010-2023 | |
| Howard Luther | 164 | 5332 | 2003-2014 | ||
| 24. | Antonio Ramos | 161 | 4081 | 2000-2008 | |
| 25. | Rene Searles | 148 | 7383 | 2011-2025 | |
| 26. | Jake Kinchen | 143 | 4878 | 2017-2029 | |
| 27. | Dan Erb | 133 | 7384 | 2009-2021 | |
| 28. | James Dickson | 128 | 3717 | 2000-2009 | |
| 29. | Joseph Flores | 125 | 5516 | 2019-2029 | |
| 30. | Mason Highsmith | 124 | 10686 | 2007-2024 | |
| 31. | Danny Rayborn | 112 | 5328 | 2000-2008 | |
| 32. | Randy McKen | 108 | 3078 | 2012-2022 | |
| 33. | Darius Mosqueda | 107 | 4124 | 2000-2011 | |
| 34. | Andrew Wilson | 103 | 3737 | 2024-2029 | |
| 35. | Mark Stone | 100 | 5743 | 2018-2029 | |
| 36. | Allen Lively | 91 | 6045 | 2011-2022 | |
| 37. | Humberto Dominguez | 88 | 3531 | 2000-2011 | |
| 38. | Todd Maher | 84 | 4549 | 2000-2008 | |
| 39. | Arron Silvia | 83 | 3452 | 2005-2013 | |
| 40. | Red Rother | 79 | 4625 | 2009-2018 | |
| Jose Abdullah | 79 | 2622 | 2000-2005 | ||
| 42. | Jesus Tabares | 78 | 3372 | 2022-2029 | |
| 43. | Josephus Thomas | 76 | 5782 | 2004-2016 | |
| 44. | Oscar Nolan | 75 | 5379 | 2019-2029 | |
| Eugene Hove | 75 | 3776 | 2007-2017 | ||
| John Honeycutt | 75 | 3832 | 2003-2013 | ||
| 47. | Jack Hesse | 73 | 2654 | 2026-2029 | |
| 48. | Frederick Traynor | 70 | 3482 | 2000-2006 | |
| 49. | Robert Souders | 69 | 2154 | 2003-2013 | |
| Joseph Sharkey | 69 | 3257 | 2000-2005 | ||
| 51. | Bates Schatz | 68 | 3542 | 2024-2029 | |
| Bob Pyne | 68 | 2749 | 2021-2029 | ||
| 53. | Joshua Sidwell | 67 | 5209 | 2014-2024 | |
| 54. | Harvey Thornton | 66 | 5456 | 2016-2029 | |
| Jeff Arnette | 66 | 4967 | 2021-2029 | ||
| Fernando Selso | 66 | 3300 | 2024-2029 | ||
| Todd Castiglia | 66 | 5873 | 2000-2016 | ||
| 58. | Tamajirou Kakuzo | 65 | 7146 | 2015-2029 | |
| 59. | Bruce Howes | 60 | 4009 | 2001-2014 | |
| Keith Johnson | 60 | 2991 | 2000-2010 | ||
| 61. | Dave Dancey | 59 | 4834 | 2020-2029 | |
| 62. | Larry Place | 57 | 2523 | 2000-2006 | |
| 63. | Looney Garmendia | 56 | 1902 | 2027-2029 | |
| 64. | Manuel Rodriguez | 55 | 6614 | 2007-2019 | |
| Abe Seemann | 55 | 5043 | 2005-2017 | ||
| 66. | Alan Gast | 54 | 1678 | 2024-2028 | |
| 67. | David Cimino | 53 | 3000 | 2009-2020 | |
| 68. | Matt Lake | 52 | 2952 | 2023-2029 | |
| 69. | Snap Collins | 49 | 2571 | 2022-2029 | |
| Brett Eisen | 49 | 3050 | 2000-2011 | ||
| 71. | Hornet Lethbridge | 47 | 1183 | 2026-2029 | |
| Hector Rodriguez | 47 | 1831 | 2000-2002 | ||
| 73. | Joe Hepler | 44 | 4874 | 2006-2016 | |
| Bill Latham | 44 | 4352 | 2007-2014 | ||
| 75. | Henry Magnan | 41 | 6019 | 2014-2027 | |
| Alexander Bologna | 41 | 1770 | 2000-2003 | ||
| 77. | Howard Pierre | 40 | 2924 | 2016-2027 | |
| William Kulas | 40 | 1838 | 2000-2009 | ||
| David Strothers | 40 | 1954 | 2000-2006 | ||
| 80. | Jim Masson | 38 | 4093 | 2016-2029 | |
| Luis Osalde | 38 | 2476 | 2021-2029 | ||
| Leon Nickles | 38 | 2183 | 2025-2029 | ||
| Roger Aker | 38 | 1694 | 2025-2029 | ||
| 84. | Terry Byrd | 37 | 1379 | 2021-2029 | |
| Bob Hamada | 37 | 2474 | 2017-2028 | ||
| Eduardo Ulibarri | 37 | 2373 | 2005-2015 | ||
| 87. | James Erickson | 36 | 4383 | 2005-2020 | |
| 88. | Vernon Rainwater | 34 | 2617 | 2003-2013 | |
| 89. | Milford Gemmill | 33 | 944 | 2000-2001 | |
| 90. | Garry Vandiver | 31 | 4892 | 2020-2029 | |
| Tanner Valencia | 31 | 1123 | 2027-2029 | ||
| 92. | George Mingham | 30 | 3211 | 2010-2023 | |
| 93. | Felippe Gazivoda | 29 | 1481 | 2024-2029 | |
| 94. | David Reddaway | 28 | 5023 | 2019-2029 | |
| Matthew Dismukes | 28 | 1941 | 2000-2005 | ||
| 96. | Antonio Defazio | 27 | 2273 | 2002-2013 | |
| 97. | Ed Parker | 26 | 3232 | 2022-2029 | |
| Micheal Harrell | 26 | 917 | 2027-2029 | ||
| 99. | Bradford Erskine | 25 | 1452 | 2014-2026 | |
| Brendan Conners | 25 | 1191 | 2005-2016 |
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