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| Second Basemen Career Hits Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Hits | PA | Years | Single Season Leaderboard |
| 1. | Summer Nelson * | 3892 | 13326 | 2000-2020 | |
| 2. | Brian Marshall * | 3322 | 12282 | 2000-2018 | |
| 3. | Seamus O'Dule * | 3103 | 11331 | 2002-2021 | |
| 4. | Mason Highsmith | 3077 | 10686 | 2007-2024 | |
| 5. | Joel Huertas | 2713 | 10198 | 2014-2029 | |
| 6. | Vin Koenig | 2513 | 9411 | 2007-2023 | |
| 7. | Lane Commons * | 2476 | 9290 | 2003-2017 | |
| 8. | Daniel Phillips | 2266 | 9012 | 2014-2028 | |
| 9. | Adam Anderson | 2166 | 8316 | 2001-2016 | |
| 10. | Matthew Wolf | 2059 | 8475 | 2015-2029 | |
| 11. | Rene Searles | 1994 | 7383 | 2011-2025 | |
| 12. | Anthony Godwin | 1883 | 8267 | 2015-2029 | |
| 13. | Rey Moncayo * | 1814 | 7698 | 2002-2014 | |
| 14. | Dan Erb | 1783 | 7384 | 2009-2021 | |
| 15. | Bob Medforth | 1775 | 6924 | 2018-2029 | |
| 16. | Tamajirou Kakuzo | 1731 | 7146 | 2015-2029 | |
| 17. | Todd Castiglia | 1719 | 5873 | 2000-2016 | |
| 18. | Zachary Matthews * | 1692 | 7672 | 2000-2012 | |
| 19. | Bobby Whittaker | 1651 | 6765 | 2010-2026 | |
| 20. | Manuel Rodriguez | 1590 | 6614 | 2007-2019 | |
| 21. | Blinky Crouch | 1549 | 6751 | 2018-2029 | |
| 22. | Mark Stone | 1469 | 5743 | 2018-2029 | |
| 23. | Allen Lively | 1467 | 6045 | 2011-2022 | |
| 24. | Ernest Meleschi | 1455 | 6493 | 2007-2019 | |
| 25. | Oscar Nolan | 1451 | 5379 | 2019-2029 | |
| 26. | Jeff Arnette | 1398 | 4967 | 2021-2029 | |
| 27. | Henry Magnan | 1391 | 6019 | 2014-2027 | |
| 28. | Henry Davis | 1386 | 6413 | 2005-2020 | |
| 29. | Ludwig Claus | 1361 | 7196 | 2005-2022 | |
| 30. | Harvey Thornton | 1360 | 5456 | 2016-2029 | |
| 31. | Cyril Foland | 1324 | 5514 | 2003-2013 | |
| 32. | David Melgoza | 1298 | 5545 | 2010-2023 | |
| 33. | Gary Crawford | 1293 | 5657 | 2000-2009 | |
| 34. | Joseph Flores | 1257 | 5516 | 2019-2029 | |
| 35. | Howard Luther | 1255 | 5332 | 2003-2014 | |
| 36. | Josephus Thomas | 1219 | 5782 | 2004-2016 | |
| 37. | Joe Hepler | 1207 | 4874 | 2006-2016 | |
| 38. | Danny Rayborn | 1187 | 5328 | 2000-2008 | |
| 39. | Red Rother | 1184 | 4625 | 2009-2018 | |
| 40. | David Reddaway | 1182 | 5023 | 2019-2029 | |
| 41. | Dave Dancey | 1150 | 4834 | 2020-2029 | |
| 42. | Joshua Sidwell | 1148 | 5209 | 2014-2024 | |
| 43. | Garry Vandiver | 1126 | 4892 | 2020-2029 | |
| 44. | Abe Seemann | 1107 | 5043 | 2005-2017 | |
| 45. | Jake Kinchen | 1100 | 4878 | 2017-2029 | |
| 46. | Todd Maher | 1073 | 4549 | 2000-2008 | |
| 47. | Jim Masson | 1042 | 4093 | 2016-2029 | |
| 48. | James Erickson | 1032 | 4383 | 2005-2020 | |
| 49. | Bill Latham | 1019 | 4352 | 2007-2014 | |
| 50. | Bruce Howes | 1016 | 4009 | 2001-2014 | |
| 51. | Andrew Wilson | 1002 | 3737 | 2024-2029 | |
| 52. | Bates Schatz | 990 | 3542 | 2024-2029 | |
| 53. | William Maxon | 968 | 4637 | 2000-2008 | |
| 54. | Joel Camacho | 921 | 3453 | 2000-2005 | |
| 55. | John Honeycutt | 919 | 3832 | 2003-2013 | |
| 56. | Antonio Ramos | 894 | 4081 | 2000-2008 | |
| 57. | Darius Mosqueda | 893 | 4124 | 2000-2011 | |
| 58. | Fernando Selso | 892 | 3300 | 2024-2029 | |
| 59. | Adrian Turgeon | 870 | 3187 | 2017-2029 | |
| 60. | Samuel Warlick | 857 | 4031 | 2001-2016 | |
| 61. | Ed Parker | 851 | 3232 | 2022-2029 | |
| 62. | Eugene Hove | 830 | 3776 | 2007-2017 | |
| 63. | James Dickson | 827 | 3717 | 2000-2009 | |
| 64. | Frederick Traynor | 818 | 3482 | 2000-2006 | |
| 65. | George Mingham | 797 | 3211 | 2010-2023 | |
| 66. | Jesus Tabares | 794 | 3372 | 2022-2029 | |
| 67. | Humberto Dominguez | 763 | 3531 | 2000-2011 | |
| 68. | Joseph Sharkey | 724 | 3257 | 2000-2005 | |
| 69. | Jack Hesse | 713 | 2654 | 2026-2029 | |
| 70. | Brett Eisen | 706 | 3050 | 2000-2011 | |
| 71. | Keith Johnson | 705 | 2991 | 2000-2010 | |
| 72. | David Cimino | 704 | 3000 | 2009-2020 | |
| 73. | Arron Silvia | 687 | 3452 | 2005-2013 | |
| 74. | Jade Sanchez | 674 | 2704 | 2025-2029 | |
| 75. | Dude Gallagher | 661 | 3298 | 2019-2029 | |
| 76. | Randy McKen | 650 | 3078 | 2012-2022 | |
| 77. | Snap Collins | 644 | 2571 | 2022-2029 | |
| 78. | Leon Nickles | 623 | 2183 | 2025-2029 | |
| 79. | Matt Lake | 621 | 2952 | 2023-2029 | |
| 80. | Bob Pyne | 609 | 2749 | 2021-2029 | |
| 81. | Luis Osalde | 600 | 2476 | 2021-2029 | |
| 82. | Howard Pierre | 593 | 2924 | 2016-2027 | |
| 83. | Bob Hamada | 566 | 2474 | 2017-2028 | |
| Jose Abdullah | 566 | 2622 | 2000-2005 | ||
| 85. | Looney Garmendia | 559 | 1902 | 2027-2029 | |
| 86. | Vernon Rainwater | 544 | 2617 | 2003-2013 | |
| 87. | Larry Place | 527 | 2523 | 2000-2006 | |
| 88. | David Strothers | 492 | 1954 | 2000-2006 | |
| 89. | Antonio Defazio | 480 | 2273 | 2002-2013 | |
| 90. | Roger Aker | 445 | 1694 | 2025-2029 | |
| 91. | Eduardo Ulibarri | 430 | 2373 | 2005-2015 | |
| 92. | Matthew Dismukes | 427 | 1941 | 2000-2005 | |
| 93. | Alexander Bologna | 413 | 1770 | 2000-2003 | |
| 94. | William Kulas | 407 | 1838 | 2000-2009 | |
| 95. | Don Tye | 397 | 1669 | 2011-2022 | |
| 96. | Hector Rodriguez | 394 | 1831 | 2000-2002 | |
| 97. | Alberto Aceves | 392 | 1893 | 2012-2021 | |
| 98. | Lynn Labrecque | 389 | 1701 | 2007-2016 | |
| 99. | Robert Souders | 388 | 2154 | 2003-2013 | |
| 100. | Bo Dimattia | 373 | 1848 | 2014-2018 |
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