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| Second Basemen Career Singles Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Singles | PA | Years | Single Season Leaderboard |
| 1. | Summer Nelson * | 2933 | 13326 | 2000-2020 | |
| 2. | Mason Highsmith | 2533 | 10686 | 2007-2024 | |
| 3. | Brian Marshall * | 2504 | 12282 | 2000-2018 | |
| 4. | Seamus O'Dule * | 2304 | 11331 | 2002-2021 | |
| 5. | Joel Huertas | 2034 | 10198 | 2014-2029 | |
| 6. | Vin Koenig | 1967 | 9411 | 2007-2023 | |
| 7. | Lane Commons * | 1645 | 9290 | 2003-2017 | |
| 8. | Daniel Phillips | 1618 | 9012 | 2014-2028 | |
| 9. | Rene Searles | 1564 | 7383 | 2011-2025 | |
| 10. | Matthew Wolf | 1435 | 8475 | 2015-2029 | |
| 11. | Adam Anderson | 1370 | 8316 | 2001-2016 | |
| 12. | Todd Castiglia | 1350 | 5873 | 2000-2016 | |
| 13. | Tamajirou Kakuzo | 1320 | 7146 | 2015-2029 | |
| 14. | Anthony Godwin | 1305 | 8267 | 2015-2029 | |
| 15. | Manuel Rodriguez | 1269 | 6614 | 2007-2019 | |
| 16. | Dan Erb | 1228 | 7384 | 2009-2021 | |
| 17. | Bob Medforth | 1201 | 6924 | 2018-2029 | |
| 18. | Mark Stone | 1190 | 5743 | 2018-2029 | |
| 19. | Bobby Whittaker | 1174 | 6765 | 2010-2026 | |
| Allen Lively | 1174 | 6045 | 2011-2022 | ||
| 21. | Rey Moncayo * | 1156 | 7698 | 2002-2014 | |
| 22. | Jeff Arnette | 1132 | 4967 | 2021-2029 | |
| 23. | Oscar Nolan | 1128 | 5379 | 2019-2029 | |
| 24. | Zachary Matthews * | 1089 | 7672 | 2000-2012 | |
| 25. | Harvey Thornton | 1063 | 5456 | 2016-2029 | |
| 26. | Blinky Crouch | 1062 | 6751 | 2018-2029 | |
| 27. | Henry Magnan | 1030 | 6019 | 2014-2027 | |
| 28. | Henry Davis | 965 | 6413 | 2005-2020 | |
| 29. | Josephus Thomas | 961 | 5782 | 2004-2016 | |
| 30. | Joe Hepler | 933 | 4874 | 2006-2016 | |
| 31. | David Reddaway | 915 | 5023 | 2019-2029 | |
| 32. | Cyril Foland | 912 | 5514 | 2003-2013 | |
| 33. | Ernest Meleschi | 897 | 6493 | 2007-2019 | |
| 34. | Red Rother | 894 | 4625 | 2009-2018 | |
| 35. | Dave Dancey | 870 | 4834 | 2020-2029 | |
| 36. | David Melgoza | 863 | 5545 | 2010-2023 | |
| 37. | Joshua Sidwell | 860 | 5209 | 2014-2024 | |
| 38. | Danny Rayborn | 858 | 5328 | 2000-2008 | |
| 39. | Jim Masson | 809 | 4093 | 2016-2029 | |
| 40. | Bill Latham | 807 | 4352 | 2007-2014 | |
| 41. | Garry Vandiver | 800 | 4892 | 2020-2029 | |
| 42. | Bruce Howes | 799 | 4009 | 2001-2014 | |
| 43. | Joseph Flores | 770 | 5516 | 2019-2029 | |
| 44. | Jake Kinchen | 766 | 4878 | 2017-2029 | |
| 45. | Howard Luther | 764 | 5332 | 2003-2014 | |
| 46. | Joel Camacho | 762 | 3453 | 2000-2005 | |
| 47. | Abe Seemann | 761 | 5043 | 2005-2017 | |
| 48. | Ludwig Claus | 760 | 7196 | 2005-2022 | |
| 49. | James Erickson | 754 | 4383 | 2005-2020 | |
| 50. | Bates Schatz | 747 | 3542 | 2024-2029 | |
| 51. | Gary Crawford | 728 | 5657 | 2000-2009 | |
| 52. | Fernando Selso | 716 | 3300 | 2024-2029 | |
| 53. | Andrew Wilson | 715 | 3737 | 2024-2029 | |
| 54. | Todd Maher | 712 | 4549 | 2000-2008 | |
| 55. | Adrian Turgeon | 705 | 3187 | 2017-2029 | |
| 56. | Ed Parker | 697 | 3232 | 2022-2029 | |
| 57. | Jesus Tabares | 622 | 3372 | 2022-2029 | |
| Samuel Warlick | 622 | 4031 | 2001-2016 | ||
| 59. | George Mingham | 618 | 3211 | 2010-2023 | |
| 60. | Darius Mosqueda | 616 | 4124 | 2000-2011 | |
| 61. | Eugene Hove | 571 | 3776 | 2007-2017 | |
| 62. | James Dickson | 541 | 3717 | 2000-2009 | |
| 63. | Frederick Traynor | 537 | 3482 | 2000-2006 | |
| 64. | Jack Hesse | 529 | 2654 | 2026-2029 | |
| 65. | David Cimino | 520 | 3000 | 2009-2020 | |
| 66. | Antonio Ramos | 518 | 4081 | 2000-2008 | |
| 67. | Jade Sanchez | 515 | 2704 | 2025-2029 | |
| William Maxon | 515 | 4637 | 2000-2008 | ||
| 69. | Leon Nickles | 514 | 2183 | 2025-2029 | |
| 70. | Dude Gallagher | 509 | 3298 | 2019-2029 | |
| 71. | John Honeycutt | 508 | 3832 | 2003-2013 | |
| 72. | Joseph Sharkey | 497 | 3257 | 2000-2005 | |
| 73. | Brett Eisen | 484 | 3050 | 2000-2011 | |
| 74. | Snap Collins | 483 | 2571 | 2022-2029 | |
| 75. | Humberto Dominguez | 480 | 3531 | 2000-2011 | |
| 76. | Keith Johnson | 475 | 2991 | 2000-2010 | |
| 77. | Luis Osalde | 467 | 2476 | 2021-2029 | |
| 78. | Arron Silvia | 463 | 3452 | 2005-2013 | |
| 79. | Matt Lake | 432 | 2952 | 2023-2029 | |
| 80. | Bob Pyne | 422 | 2749 | 2021-2029 | |
| 81. | Bob Hamada | 420 | 2474 | 2017-2028 | |
| 82. | Vernon Rainwater | 412 | 2617 | 2003-2013 | |
| 83. | Howard Pierre | 396 | 2924 | 2016-2027 | |
| 84. | Looney Garmendia | 390 | 1902 | 2027-2029 | |
| 85. | Randy McKen | 385 | 3078 | 2012-2022 | |
| 86. | Antonio Defazio | 382 | 2273 | 2002-2013 | |
| 87. | David Strothers | 373 | 1954 | 2000-2006 | |
| 88. | Jose Abdullah | 357 | 2622 | 2000-2005 | |
| 89. | Roger Aker | 330 | 1694 | 2025-2029 | |
| 90. | Don Tye | 327 | 1669 | 2011-2022 | |
| 91. | Larry Place | 320 | 2523 | 2000-2006 | |
| 92. | Eduardo Ulibarri | 315 | 2373 | 2005-2015 | |
| 93. | William Kulas | 304 | 1838 | 2000-2009 | |
| 94. | Alberto Aceves | 302 | 1893 | 2012-2021 | |
| 95. | Bo Dimattia | 301 | 1848 | 2014-2018 | |
| 96. | Lynn Labrecque | 300 | 1701 | 2007-2016 | |
| 97. | Matthew Dismukes | 296 | 1941 | 2000-2005 | |
| 98. | Albert Estrada | 273 | 1636 | 2000-2012 | |
| 99. | Freddy Lozano | 271 | 1131 | 2000-2005 | |
| Alexander Bologna | 271 | 1770 | 2000-2003 |
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