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| Career Post-Season Strikeouts per 9IP Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Strikeouts per 9IP | IP | Years | Single Season Leaderboard |
| 1. | David Evans | 12.68 | 22.0 | 2001-2002 | |
| 2. | Joseph Holland | 12.23 | 28.0 | 2006-2020 | |
| 3. | Joseph Seybert | 11.49 | 31.3 | 2003-2003 | |
| 4. | Richard Eaker | 10.80 | 33.3 | 2000-2002 | |
| 5. | Gregory Hart | 10.80 | 20.0 | 2000-2001 | |
| 6. | Jewel Brown | 10.42 | 27.7 | 2002-2010 | |
| 7. | Steven Williams * | 10.32 | 29.7 | 2008-2008 | |
| 8. | Jose Valdovinos | 10.29 | 28.0 | 2000-2000 | |
| 9. | Deangelo Ramos * | 10.19 | 76.0 | 2006-2019 | |
| 10. | Samson Steele * | 9.88 | 27.3 | 2000-2002 | |
| 11. | Simon Munoz | 9.87 | 21.0 | 2002-2008 | |
| 12. | Dustin Carrasquillo | 9.84 | 89.7 | 2001-2009 | |
| 13. | Lee Jarboe | 9.62 | 24.3 | 2001-2007 | |
| 14. | Harry Swint | 9.59 | 25.3 | 2003-2003 | |
| 15. | Denny Truman | 9.51 | 23.7 | 2023-2029 | |
| 16. | David Echegaray | 9.49 | 213.3 | 2004-2023 | |
| 17. | Herbert Castillo | 9.25 | 59.3 | 2027-2029 | |
| 18. | Kelly Giuliani | 9.24 | 25.3 | 2002-2004 | |
| 19. | Keenan Brochu | 9.20 | 31.3 | 2000-2003 | |
| 20. | Edgardo Castillo * | 8.93 | 79.7 | 2004-2015 | |
| 21. | Randy Kennedy | 8.71 | 20.7 | 2008-2008 | |
| 22. | Ryan Turner * | 8.63 | 288.0 | 2002-2021 | |
| 23. | Skip Burns | 8.51 | 115.3 | 2010-2019 | |
| 24. | Claudio Romeo | 8.50 | 36.0 | 2002-2006 | |
| 25. | James Yim * | 8.49 | 124.0 | 2005-2012 | |
| 26. | Sauron Evil | 8.46 | 27.7 | 2000-2006 | |
| 27. | Jose Langlois | 8.35 | 60.3 | 2006-2018 | |
| 28. | Robby Butler | 8.31 | 52.0 | 2000-2002 | |
| 29. | Tyrell Silvera | 8.24 | 27.3 | 2000-2001 | |
| 30. | Danny Day | 8.24 | 160.7 | 2016-2022 | |
| 31. | Alfredo Jurez | 8.10 | 23.3 | 2027-2029 | |
| 32. | Willie Marshall | 8.08 | 45.7 | 2001-2005 | |
| 33. | Fred Washington | 8.08 | 81.3 | 2005-2017 | |
| 34. | Armando Quinonez * | 7.97 | 101.7 | 2001-2006 | |
| 35. | Alex Ramirez | 7.96 | 89.3 | 2004-2014 | |
| 36. | Richard San Juan | 7.89 | 73.0 | 2021-2029 | |
| 37. | Donald Granger * | 7.83 | 23.0 | 2004-2013 | |
| 38. | Paul Harrington | 7.78 | 63.7 | 2002-2006 | |
| 39. | Malik Meng | 7.75 | 69.6 | 2000-2007 | |
| 40. | Francisco Apodaca | 7.72 | 25.7 | 2002-2013 | |
| 41. | Ben Lamela | 7.67 | 263.0 | 2009-2022 | |
| 42. | Robert Dolin | 7.66 | 22.3 | 2001-2007 | |
| 43. | Leon Collins | 7.49 | 57.7 | 2017-2020 | |
| 44. | Lamar Fox | 7.49 | 33.7 | 2014-2021 | |
| 45. | Joseph Smartt | 7.48 | 169.6 | 2002-2012 | |
| 46. | Donte Dasilva | 7.46 | 54.3 | 2007-2013 | |
| 47. | Wayne Sorely | 7.45 | 77.3 | 2027-2029 | |
| 48. | Russell Serra | 7.43 | 23.0 | 2001-2004 | |
| 49. | Ramon Cordova | 7.42 | 168.6 | 2017-2029 | |
| 50. | Dmitrij Mitskevich | 7.40 | 86.3 | 2002-2005 |
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