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| Shortstops Career Strikeouts Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Strikeouts | PA | Years | Single Season Leaderboard |
| 1. | Joseph Mentzer | 1420 | 6325 | 2000-2010 | |
| 2. | Jerrold Dukes | 1404 | 9087 | 2008-2024 | |
| 3. | Jason Kroner * | 1259 | 10707 | 2000-2018 | |
| 4. | Alex Sullins | 1192 | 8750 | 2011-2025 | |
| 5. | Chris Lott | 1145 | 8546 | 2005-2018 | |
| 6. | Rudy Lareau | 1132 | 7843 | 2010-2025 | |
| 7. | Michael Koo Jr * | 1035 | 12588 | 2000-2019 | |
| 8. | Casey Wabash | 923 | 6774 | 2014-2026 | |
| 9. | Matt McQuade * | 916 | 10532 | 2003-2020 | |
| 10. | Andrew Brown | 911 | 7828 | 2001-2016 | |
| 11. | Tanner Chayse * | 887 | 11089 | 2000-2017 | |
| 12. | Steven Wynn | 886 | 4964 | 2000-2012 | |
| 13. | James Hendricks | 870 | 4586 | 2000-2008 | |
| 14. | Richard Tasker | 862 | 4861 | 2004-2017 | |
| 15. | Jeffrey Pyles | 848 | 4744 | 2000-2015 | |
| 16. | Chris Federith | 830 | 6290 | 2019-2029 | |
| 17. | Luis Ortiz | 805 | 8272 | 2015-2029 | |
| 18. | Gandalf Greyheme * | 802 | 11069 | 2003-2020 | |
| 19. | Mark Delia * | 801 | 11162 | 2000-2018 | |
| 20. | Archy Miller Jr | 788 | 7926 | 2006-2024 | |
| 21. | Robert Petro | 776 | 5406 | 2016-2029 | |
| 22. | Matthew Maglio | 773 | 7035 | 2005-2019 | |
| 23. | Lane Greene | 744 | 6063 | 2008-2020 | |
| 24. | Norman Bates | 742 | 10477 | 2002-2020 | |
| 25. | Flyswatter Pentecost | 715 | 5196 | 2020-2029 | |
| 26. | Santo Tedesco | 695 | 6445 | 2019-2029 | |
| 27. | Mark Hall | 678 | 7290 | 2011-2023 | |
| 28. | Manuel Talamantez | 669 | 5737 | 2005-2017 | |
| 29. | Lazlo Szabonagy | 662 | 6993 | 2005-2021 | |
| 30. | Joe Berard | 659 | 4254 | 2007-2019 | |
| 31. | Albert Cepeda | 658 | 4170 | 2000-2010 | |
| 32. | Timothy Fortier | 631 | 4049 | 2013-2022 | |
| 33. | Armand Manning | 614 | 2874 | 2001-2010 | |
| 34. | Lester Griffey | 601 | 5401 | 2013-2029 | |
| 35. | James Evenson | 599 | 5017 | 2019-2029 | |
| 36. | David Bowers | 588 | 3463 | 2011-2022 | |
| 37. | Tony Luna | 573 | 4525 | 2013-2023 | |
| 38. | Francisco Magana | 571 | 2648 | 2000-2003 | |
| 39. | Leo Ryan | 566 | 3202 | 2000-2010 | |
| 40. | Zack Loranger | 562 | 3339 | 2010-2019 | |
| 41. | Carol Hoover | 542 | 2507 | 2000-2008 | |
| 42. | Mark Risch | 525 | 2452 | 2000-2013 | |
| Lanny Pennock | 525 | 4064 | 2000-2010 | ||
| 44. | Clinton Averett | 523 | 2752 | 2000-2004 | |
| 45. | Jeff Magee | 521 | 4521 | 2017-2029 | |
| 46. | Hikaro Kinji | 514 | 2115 | 2002-2008 | |
| 47. | Ramone Arais | 513 | 3330 | 2023-2029 | |
| 48. | Matthew Courtney | 512 | 3421 | 2015-2026 | |
| 49. | Willie Tyler | 504 | 4174 | 2003-2018 | |
| 50. | Cipri Font | 494 | 4610 | 2012-2022 | |
| 51. | Mitch Nickle | 483 | 2338 | 2003-2013 | |
| 52. | Garry Piccirillo | 464 | 2677 | 2000-2004 | |
| 53. | Rafael Pocovi | 446 | 3671 | 2024-2029 | |
| 54. | Marcelo Cancio | 428 | 3060 | 2016-2024 | |
| 55. | Joseph Gardiner | 424 | 7992 | 2008-2022 | |
| 56. | Patrick Cleek | 422 | 2768 | 2000-2007 | |
| 57. | Bill Prosser | 421 | 2742 | 2016-2029 | |
| Robert Wyatt | 421 | 4949 | 2001-2011 | ||
| 59. | Timothy Montag | 412 | 4444 | 2007-2015 | |
| Mauricio Decosta | 412 | 2992 | 2002-2012 | ||
| 61. | Jeremy Austin | 407 | 2614 | 2023-2029 | |
| 62. | John McDonald | 379 | 7704 | 2005-2018 | |
| 63. | Mark Vanman | 378 | 3355 | 2020-2029 | |
| 64. | Sherm Allred | 377 | 2764 | 2016-2029 | |
| Rex Spikes | 377 | 5012 | 2006-2019 | ||
| 66. | Don Lomax | 365 | 1592 | 2002-2008 | |
| 67. | Wendell Granger | 356 | 1946 | 2000-2004 | |
| 68. | Hector Castruita | 346 | 2447 | 2020-2029 | |
| 69. | Jose Decambra | 339 | 6444 | 2009-2021 | |
| 70. | Benjamin Vasquez | 338 | 3503 | 2000-2008 | |
| 71. | Jarvis Henderson | 337 | 2344 | 2020-2028 | |
| 72. | Richard Steward | 335 | 1848 | 2000-2006 | |
| 73. | Timothy Brooks | 332 | 2247 | 2018-2028 | |
| 74. | Matro Pacheco | 329 | 1749 | 2027-2029 | |
| 75. | Earl McEvoy | 328 | 2266 | 2022-2029 | |
| 76. | Drew Phillips | 318 | 2050 | 2025-2029 | |
| 77. | Bob Duran | 316 | 3226 | 2023-2029 | |
| 78. | Salvino Derivera | 313 | 3109 | 2023-2029 | |
| 79. | Luther Shelton | 310 | 2078 | 2020-2029 | |
| 80. | Bradley Davis | 309 | 1839 | 2000-2003 | |
| 81. | William Masi | 306 | 1535 | 2000-2010 | |
| 82. | Wilfredo Grajeda | 305 | 1706 | 2000-2004 | |
| 83. | Kyle Warner | 302 | 2227 | 2021-2027 | |
| 84. | Anier Guiterrey | 298 | 1848 | 2018-2029 | |
| 85. | Jerry Pyne | 291 | 1803 | 2000-2004 | |
| 86. | Pat Eckard | 289 | 2088 | 2025-2029 | |
| 87. | Bill Lanctot | 286 | 2352 | 2000-2012 | |
| 88. | Carlos Gomez | 279 | 3805 | 2003-2013 | |
| 89. | Joseph Tucker | 268 | 1368 | 2002-2008 | |
| 90. | Donald Toman | 263 | 5643 | 2004-2015 | |
| 91. | Christopher Kass | 254 | 1506 | 2000-2007 | |
| 92. | Lesley Hamm | 252 | 2173 | 2024-2029 | |
| 93. | Lloyd Snavely | 248 | 1530 | 2017-2027 | |
| 94. | Pedro Lomeli | 247 | 2381 | 2008-2019 | |
| 95. | James Ibanez | 239 | 2343 | 2000-2006 | |
| 96. | Fred Haigney | 238 | 3866 | 2023-2029 | |
| 97. | Jarrod Jennings | 230 | 1419 | 2018-2023 | |
| 98. | Angelo De Leon | 220 | 1850 | 2018-2025 | |
| 99. | Ron Salas | 219 | 2333 | 2023-2029 | |
| 100. | Bill Graham | 218 | 2570 | 2018-2027 |
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