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| Catchers Single-Season Strikeouts Leaderboard | |
| * - Indicates Hall of Fame |
| Rank | Player | Strikeouts | PA | Year | Career Leaderboard |
| 1. | Gene Tetrault | 138 | 608 | 2002 | |
| 2. | Antonio Hernandez | 135 | 600 | 2004 | |
| 3. | Gene Tetrault | 133 | 608 | 2000 | |
| 4. | Anthony Pooler | 132 | 517 | 2007 | |
| Lee Bolden | 132 | 558 | 2004 | ||
| 6. | Osvaldo Ramos | 131 | 458 | 2006 | |
| 7. | Jackie Perez | 130 | 563 | 2002 | |
| 8. | Bill Hill | 128 | 512 | 2006 | |
| 9. | Gene Tetrault | 125 | 554 | 2009 | |
| 10. | Helmut Tuna | 124 | 519 | 2007 | |
| Jim Godbey | 124 | 651 | 2001 | ||
| 12. | Jackie Martinez | 123 | 542 | 2006 | |
| 13. | Jackie Perez | 122 | 617 | 2000 | |
| 14. | Arthur McIlhenny | 120 | 548 | 2016 | |
| In-Sun An | 120 | 600 | 2013 | ||
| 16. | Arthur McIlhenny | 119 | 574 | 2015 | |
| Willie Franklin | 119 | 517 | 2002 | ||
| Jackie Perez | 119 | 598 | 2001 | ||
| Matthew Finck | 119 | 589 | 2001 | ||
| Bernard Ramos | 119 | 669 | 2000 | ||
| Richard Ruffner | 119 | 646 | 2000 | ||
| 22. | Johney Yoon | 118 | 541 | 2009 | |
| Bill Hill | 118 | 486 | 2008 | ||
| 24. | Malachi Sain * | 117 | 573 | 2003 | |
| 25. | Osvaldo Ramos | 116 | 464 | 2007 | |
| Luis Archuleta | 116 | 525 | 2001 | ||
| 27. | Jim Godbey | 115 | 547 | 2008 | |
| Gene Tetrault | 115 | 490 | 2003 | ||
| 29. | Jackie Martinez | 114 | 460 | 2008 | |
| Antonio Hernandez | 114 | 566 | 2005 | ||
| Osvaldo Ramos | 114 | 585 | 2002 | ||
| Antonio Hernandez | 114 | 613 | 2001 | ||
| Tracy Jordan | 114 | 634 | 2000 | ||
| 34. | In-Sun An | 113 | 588 | 2015 | |
| 35. | Arthur McIlhenny | 112 | 577 | 2018 | |
| Jackie Perez | 112 | 500 | 2004 | ||
| Malachi Sain * | 112 | 647 | 2001 | ||
| 38. | Martin Holtz | 111 | 570 | 2006 | |
| Bill Hill | 111 | 473 | 2005 | ||
| James Reed | 111 | 543 | 2002 | ||
| Luis Archuleta | 111 | 610 | 2000 | ||
| Malachi Sain * | 111 | 552 | 2000 | ||
| 43. | Martin Holtz | 110 | 560 | 2005 | |
| Bill Hill | 110 | 482 | 2004 | ||
| Antonio Hernandez | 110 | 591 | 2003 | ||
| Willie Franklin | 110 | 512 | 2003 | ||
| 47. | Danny Berthelot | 109 | 524 | 2025 | |
| Anthony Pooler | 109 | 429 | 2005 | ||
| James Young | 109 | 646 | 2002 | ||
| Mark Plum | 109 | 495 | 2002 | ||
| 51. | Richard Ruffner | 108 | 511 | 2005 | |
| Jon Manley | 108 | 625 | 2000 | ||
| 53. | Richard Baxley | 107 | 533 | 2015 | |
| Arthur McIlhenny | 107 | 540 | 2009 | ||
| John Ellsworth | 107 | 492 | 2002 | ||
| 56. | Arthur McIlhenny | 106 | 537 | 2010 | |
| Osvaldo Ramos | 106 | 485 | 2004 | ||
| Johney Yoon | 106 | 675 | 2000 | ||
| James Reed | 106 | 608 | 2000 | ||
| 60. | Anthony Pooler | 105 | 377 | 2008 | |
| Malachi Sain * | 105 | 618 | 2002 | ||
| 62. | Richard Baxley | 104 | 536 | 2013 | |
| Helmut Tuna | 104 | 567 | 2008 | ||
| Bill Hill | 104 | 478 | 2002 | ||
| 65. | Amoldo Llanas | 103 | 626 | 2029 | |
| In-Sun An | 103 | 597 | 2014 | ||
| Arthur McIlhenny | 103 | 554 | 2013 | ||
| Jackie Martinez | 103 | 433 | 2007 | ||
| Anthony Pooler | 103 | 407 | 2006 | ||
| James Reed | 103 | 609 | 2001 | ||
| Osvaldo Ramos | 103 | 568 | 2000 | ||
| 72. | Arthur McIlhenny | 102 | 447 | 2008 | |
| Bill Hill | 102 | 433 | 2007 | ||
| Mark Plum | 102 | 486 | 2003 | ||
| Antonio Hernandez | 102 | 587 | 2002 | ||
| Mark Plum | 102 | 505 | 2001 | ||
| 77. | Vernon Castanon | 101 | 553 | 2013 | |
| Jackie Perez | 101 | 468 | 2006 | ||
| 79. | Neron Ricardez | 100 | 605 | 2027 | |
| In-Sun An | 100 | 570 | 2012 | ||
| Jackie Martinez | 100 | 538 | 2010 | ||
| Osvaldo Ramos | 100 | 598 | 2001 | ||
| 83. | In-Sun An | 99 | 539 | 2018 | |
| Troy Castiglia | 99 | 443 | 2013 | ||
| Christopher Ferrante * | 99 | 591 | 2004 | ||
| Abel Moore | 99 | 465 | 2002 | ||
| Johney Yoon | 99 | 664 | 2001 | ||
| 88. | Frisco Garrido | 98 | 665 | 2027 | |
| Johney Yoon | 98 | 568 | 2008 | ||
| Johney Yoon | 98 | 612 | 2006 | ||
| Matthew Strom | 98 | 553 | 2004 | ||
| Jackie Perez | 98 | 481 | 2003 | ||
| 93. | Arthur McIlhenny | 97 | 577 | 2011 | |
| In-Sun An | 97 | 567 | 2011 | ||
| James Easson | 97 | 492 | 2007 | ||
| 96. | Glenn Steger | 96 | 640 | 2028 | |
| Danny Berthelot | 96 | 550 | 2023 | ||
| In-Sun An | 96 | 556 | 2019 | ||
| Arthur McIlhenny | 96 | 556 | 2012 | ||
| Osvaldo Ramos | 96 | 444 | 2005 |
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