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| Third Basemen Career Strikeouts Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Strikeouts | PA | Years | Single Season Leaderboard |
| 1. | Christopher Stormes * | 1833 | 10512 | 2006-2023 | |
| 2. | Grady McDonaghey * | 1487 | 8964 | 2006-2020 | |
| 3. | Victor Gullo | 1388 | 9423 | 2012-2027 | |
| 4. | Michael Mooney | 1339 | 6385 | 2003-2015 | |
| 5. | Jeffrey Foxwell | 1246 | 7836 | 2014-2027 | |
| 6. | Tyson Bacon * | 1133 | 13464 | 2000-2022 | |
| Jared Guidi | 1133 | 5980 | 2000-2010 | ||
| 8. | Andrew Rath | 1092 | 6919 | 2002-2015 | |
| 9. | Issac Phillips | 1076 | 8097 | 2012-2029 | |
| Carlos Pena | 1076 | 5789 | 2009-2022 | ||
| 11. | Barney King | 1012 | 5320 | 2000-2009 | |
| 12. | Dicky Kerns | 912 | 7068 | 2007-2022 | |
| 13. | Felix Soto | 851 | 3974 | 2000-2009 | |
| 14. | Numbers Steven | 844 | 4241 | 2001-2013 | |
| 15. | Gene Halpern | 843 | 8036 | 2009-2022 | |
| 16. | Deshawn Cobb | 820 | 7263 | 2000-2011 | |
| 17. | Jefferson Session | 815 | 3787 | 2001-2010 | |
| 18. | Aaron Dunigan | 809 | 5133 | 2000-2011 | |
| 19. | Donnie Bremer | 800 | 7981 | 2017-2029 | |
| 20. | Robert Smith | 797 | 3803 | 2000-2008 | |
| 21. | Julian Stanek | 783 | 4021 | 2000-2008 | |
| 22. | Kent Mumford | 780 | 5644 | 2000-2010 | |
| 23. | Bill Lalonde | 777 | 5561 | 2000-2010 | |
| 24. | Richard Jerkins | 774 | 4962 | 2016-2027 | |
| 25. | Cody Dougherty | 761 | 4836 | 2018-2029 | |
| 26. | Sanford Powers | 760 | 10625 | 2014-2029 | |
| 27. | Rosario Villalvazo | 753 | 4271 | 2000-2007 | |
| 28. | Ralph Carraway | 744 | 4151 | 2000-2012 | |
| 29. | August Osvald | 720 | 5322 | 2013-2028 | |
| 30. | Harold Cunningham | 714 | 3519 | 2000-2010 | |
| 31. | Guadalupe Delacruz | 656 | 4547 | 2005-2018 | |
| 32. | Frank Gillbard | 652 | 6457 | 2018-2029 | |
| 33. | Jose Chavero | 618 | 4633 | 2022-2029 | |
| 34. | Robert Leppert | 616 | 6405 | 2011-2025 | |
| 35. | John Maccord | 612 | 4202 | 2022-2029 | |
| Almedar Noche | 612 | 8758 | 2008-2024 | ||
| 37. | Bill Eisenhart | 598 | 3390 | 2024-2029 | |
| 38. | Denver Robinson | 584 | 5577 | 2014-2026 | |
| 39. | Charles Vanwormer | 583 | 5676 | 2003-2016 | |
| 40. | Harley Race | 573 | 3391 | 2000-2007 | |
| 41. | Wesley Maricich | 565 | 4762 | 2014-2026 | |
| 42. | Leonel Lagunes | 558 | 6388 | 2018-2029 | |
| 43. | Luis Gallup | 554 | 5518 | 2008-2021 | |
| 44. | Danny Carruth | 541 | 3981 | 2015-2027 | |
| 45. | Marco Jaramillo | 540 | 2831 | 2009-2019 | |
| 46. | Lucio Costello | 529 | 5363 | 2019-2029 | |
| 47. | Nightmare Massengill | 520 | 5030 | 2021-2029 | |
| 48. | Ernie Brandt | 511 | 4139 | 2004-2017 | |
| 49. | Stephen Curran | 509 | 6821 | 2018-2029 | |
| 50. | Faustino Jimenez | 496 | 4618 | 2015-2026 | |
| 51. | Roby Delpratt | 480 | 2472 | 2017-2029 | |
| 52. | Phil Schenck | 468 | 3826 | 2019-2029 | |
| 53. | Raymond Berkeley | 453 | 2336 | 2000-2004 | |
| 54. | Adolph Egerton | 446 | 2915 | 2019-2029 | |
| 55. | Martin Albruce | 445 | 2824 | 2008-2017 | |
| 56. | Jesus Carbajal | 442 | 2000 | 2000-2004 | |
| 57. | Carmelo Fons * | 440 | 9026 | 2005-2021 | |
| 58. | Joshua Heiden | 433 | 2529 | 2000-2006 | |
| 59. | Eric Algarin | 431 | 3868 | 2002-2013 | |
| 60. | Domingo Valls | 428 | 2798 | 2009-2019 | |
| 61. | Toney Resendiz | 424 | 2203 | 2000-2006 | |
| 62. | Donald Gilmour | 416 | 2759 | 2000-2005 | |
| Bertram Hitchcock | 416 | 2334 | 2000-2005 | ||
| 64. | Bill Eatman | 408 | 2113 | 2000-2003 | |
| 65. | David Donoho | 395 | 6675 | 2004-2016 | |
| 66. | Cisco Delgado | 391 | 3802 | 2021-2029 | |
| 67. | James Renken | 390 | 2467 | 2000-2005 | |
| 68. | Ramon Valero | 383 | 4473 | 2001-2013 | |
| 69. | Rodolfo Lopez | 378 | 4069 | 2000-2009 | |
| 70. | Mack Outlaw | 366 | 3183 | 2025-2029 | |
| Jared Whobrey | 366 | 2997 | 2004-2018 | ||
| 72. | Engle Stark | 361 | 3138 | 2015-2023 | |
| 73. | Spooner Shenk | 357 | 5457 | 2021-2029 | |
| 74. | Guille Gonzalez | 356 | 2156 | 2014-2025 | |
| 75. | Ross Barth | 352 | 3260 | 2023-2029 | |
| 76. | Ronaldo Vera | 343 | 4204 | 2001-2014 | |
| 77. | Chris Trosclair | 340 | 2723 | 2008-2020 | |
| 78. | Shane Kilroy | 334 | 2405 | 2026-2029 | |
| 79. | Luis Wooton | 325 | 5225 | 2007-2019 | |
| Jason Leto | 325 | 1423 | 2005-2012 | ||
| 81. | Jay Sena | 323 | 1571 | 2000-2004 | |
| 82. | Dennis Paulson | 320 | 1659 | 2013-2015 | |
| 83. | Norman Sweatman | 319 | 1645 | 2002-2009 | |
| 84. | Walter Vega | 316 | 4870 | 2005-2015 | |
| David Hanson | 316 | 1379 | 2005-2008 | ||
| 86. | Samuel Cortes | 314 | 2118 | 2000-2003 | |
| 87. | Darryl Wyatt | 301 | 1366 | 2000-2007 | |
| 88. | Braulio Azicri | 300 | 2230 | 2018-2029 | |
| 89. | Godfredo Comotho | 297 | 2619 | 2023-2029 | |
| 90. | Alfred Rieger | 288 | 1609 | 2000-2011 | |
| 91. | Alvaro Matz | 287 | 1436 | 2000-2006 | |
| Gregory Thoma | 287 | 1805 | 2000-2004 | ||
| 93. | Howard Bittinger | 282 | 1667 | 2015-2022 | |
| 94. | Trooper California | 272 | 4434 | 2019-2028 | |
| 95. | Gunner Macangus | 270 | 2168 | 2019-2029 | |
| 96. | Kyle Thorpe | 248 | 1305 | 2015-2022 | |
| 97. | James Barrett | 242 | 1721 | 2000-2007 | |
| 98. | Scruffy Bosques | 222 | 1891 | 2022-2029 | |
| 99. | Art Anderson | 217 | 1382 | 2018-2029 | |
| 100. | Alex Gonzalez | 211 | 1331 | 2001-2012 |
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