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| Career Shutouts Leaderboard | |
| * - Indicates Hall of Fame Bold - Indicates active player |
| Rank | Player | Shutouts | IP | Years | Single Season Leaderboard |
| 1. | James Yim * | 52 | 4445.9 | 2003-2021 | |
| 2. | Edgardo Castillo * | 39 | 3758.6 | 2001-2018 | |
| 3. | Ryan Turner * | 38 | 3744.9 | 2001-2021 | |
| 4. | Kevin Smith | 37 | 2599.0 | 2019-2029 | |
| 5. | Ralph Ives | 35 | 2623.6 | 2018-2029 | |
| 6. | Richard San Juan | 33 | 3143.3 | 2017-2029 | |
| 7. | Kelvin Palen | 32 | 2641.3 | 2000-2010 | |
| 8. | Chad Schmidt | 27 | 3346.6 | 2015-2029 | |
| Dennis Morelock * | 27 | 4013.6 | 2003-2017 | ||
| Thomas Showers * | 27 | 3348.0 | 2000-2013 | ||
| Aaron Bacon * | 27 | 3356.0 | 2000-2012 | ||
| 12. | David Echegaray | 26 | 4812.6 | 2003-2026 | |
| Hugh Hoots | 26 | 3766.6 | 2002-2018 | ||
| 14. | Osvaldo Pedraza | 25 | 3311.0 | 2003-2017 | |
| 15. | James Alexander | 22 | 2806.6 | 2011-2026 | |
| Albert Olmos | 22 | 3489.6 | 2000-2014 | ||
| Richard Hirsh | 22 | 3209.9 | 2000-2012 | ||
| 18. | Lowell Stang * | 21 | 2987.9 | 2007-2021 | |
| Robert Slack | 21 | 2725.3 | 2006-2020 | ||
| Tobias Escobar | 21 | 2817.9 | 2006-2019 | ||
| Lucas Lara | 21 | 2535.0 | 2004-2017 | ||
| Andrew Albury | 21 | 2407.3 | 2001-2014 | ||
| Blaine Titsworth | 21 | 1930.6 | 2000-2009 | ||
| 24. | Scott Bartell | 20 | 4101.3 | 2003-2021 | |
| Mark Torrence | 20 | 2896.3 | 2002-2015 | ||
| Armand Banuelos | 20 | 3088.0 | 2000-2012 | ||
| 27. | Humberto Deleon | 19 | 3174.9 | 2014-2029 | |
| Roderigo Pequero | 19 | 2668.6 | 2018-2029 | ||
| Dennis Wright * | 19 | 3380.6 | 2001-2014 | ||
| J.J. Cobb | 19 | 3210.6 | 2000-2014 | ||
| 31. | Benicio Andaverde | 18 | 2653.3 | 2016-2029 | |
| Abraham Grayston | 18 | 3311.3 | 2006-2022 | ||
| Samson Steele * | 18 | 2596.0 | 2000-2011 | ||
| 34. | Al West | 17 | 2725.6 | 2017-2029 | |
| Steven Williams * | 17 | 3524.0 | 2002-2017 | ||
| 36. | Higinio Delmonte | 16 | 3025.3 | 2014-2029 | |
| Chale Crespa | 16 | 2354.0 | 2019-2029 | ||
| Carlos Horizon | 16 | 2301.0 | 2020-2029 | ||
| Manuel Nieves | 16 | 2186.3 | 2020-2029 | ||
| Wilfredo Arroyo | 16 | 1658.6 | 2023-2029 | ||
| Alfred Marenco | 16 | 2677.0 | 2005-2016 | ||
| 42. | Russ Gobbler | 15 | 2781.6 | 2016-2029 | |
| Bobby Williams | 15 | 2170.3 | 2019-2029 | ||
| Skip Burns | 15 | 4027.6 | 2001-2020 | ||
| Donte Dasilva | 15 | 3018.0 | 2003-2017 | ||
| Benjamin Alcala | 15 | 2609.6 | 2000-2014 | ||
| Jeffrey Cargo | 15 | 2881.3 | 2000-2011 | ||
| 48. | Ramon Cordova | 14 | 2756.6 | 2017-2029 | |
| John Andujar | 14 | 2299.3 | 2018-2029 | ||
| Leo Cleland * | 14 | 2815.6 | 2004-2017 | ||
| Jeeves Vanhooten | 14 | 3186.9 | 2000-2014 | ||
| Roger Morrison | 14 | 2573.6 | 2002-2013 | ||
| Leonard Lubbers | 14 | 2356.6 | 2003-2013 | ||
| Malik Meng | 14 | 2438.6 | 2000-2009 | ||
| 55. | Ronaldo Laguna | 13 | 2574.0 | 2017-2029 | |
| Gilbert Giglio | 13 | 2069.3 | 2014-2029 | ||
| Armando Mesta | 13 | 1366.7 | 2023-2029 | ||
| Mark Trowers | 13 | 3535.9 | 2010-2025 | ||
| Ben Lamela | 13 | 3342.6 | 2008-2025 | ||
| Chet McKie | 13 | 2146.0 | 2013-2023 | ||
| Xavier Josephs | 13 | 2994.6 | 2003-2018 | ||
| Chris Curcio | 13 | 1235.3 | 2009-2016 | ||
| Randy Kennedy | 13 | 2598.6 | 2000-2010 | ||
| Marvin Arnott | 13 | 1992.6 | 2000-2010 | ||
| 65. | Paul Hall | 12 | 2664.0 | 2018-2029 | |
| Christopher Millar | 12 | 2633.3 | 2014-2029 | ||
| Willie Wilson | 12 | 1936.6 | 2017-2029 | ||
| Danny Day | 12 | 2527.6 | 2014-2026 | ||
| Emeril Loux | 12 | 2540.0 | 2004-2018 | ||
| Ringo Russmyer | 12 | 2224.0 | 2007-2018 | ||
| George Stoehr | 12 | 2144.0 | 2002-2014 | ||
| Gregory Hart | 12 | 2858.3 | 2000-2012 | ||
| Thomas Maurer | 12 | 2171.9 | 2001-2012 | ||
| Willie Marshall | 12 | 1673.3 | 2000-2008 | ||
| Kenneth Eshleman | 12 | 1301.6 | 2000-2006 | ||
| 76. | Wayne Sorely | 11 | 1648.0 | 2021-2029 | |
| Dan Coningsby | 11 | 1388.0 | 2023-2029 | ||
| Kazuma Sen | 11 | 2533.0 | 2016-2028 | ||
| Gary Simmons | 11 | 2262.6 | 2017-2028 | ||
| Geoff Stagner | 11 | 2609.0 | 2011-2025 | ||
| Rusty Skittles | 11 | 2706.3 | 2007-2020 | ||
| Jack Eldredge | 11 | 2352.9 | 2006-2019 | ||
| Santos Quinonez | 11 | 1849.0 | 2000-2009 | ||
| 84. | Jacob Perl | 10 | 2679.6 | 2016-2029 | |
| Charles Lewandowski | 10 | 2454.3 | 2017-2029 | ||
| Powell Hoffman | 10 | 2091.7 | 2020-2029 | ||
| Artur Sax | 10 | 2590.6 | 2013-2025 | ||
| Galon Thrace | 10 | 2419.3 | 2014-2024 | ||
| Art Toczek * | 10 | 2240.3 | 2011-2023 | ||
| Paul Knutson | 10 | 2506.3 | 2005-2018 | ||
| Matthew Bedard | 10 | 2565.3 | 2004-2015 | ||
| Gene Foxworth | 10 | 2256.6 | 2001-2012 | ||
| Christopher Kearns | 10 | 2471.0 | 2000-2010 | ||
| Michael Hesson | 10 | 1494.0 | 2000-2010 | ||
| 95. | Benny Suarez | 9 | 2730.9 | 2016-2029 | |
| Jonathan Alexander | 9 | 2154.6 | 2019-2029 | ||
| Salvatore Perez | 9 | 1652.6 | 2022-2029 | ||
| Pete Leighburn | 9 | 1550.7 | 2023-2029 | ||
| Charlie Hester | 9 | 2308.3 | 2017-2028 | ||
| John Munson | 9 | 2152.3 | 2016-2026 |
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